| CAS
NO. |
69-72-7 |
|
| EINECS
NO. |
200-712-3 |
| FORMULA |
HOC6H4COOH |
| MOL
WT. |
138.12 |
| H.S.
CODE |
2918.21 |
| TOXICITY |
Oral
rat LD50: 891 mg/kg |
| SYNONYMS |
o-Hydroxybenzoic acid; Phenol-2-carboxylic acid; |
| Salonil; 2-Hydroxybenzoic acid;
2-Hydroxybenzenecarboxylic acid; 2-Carboxyphenol; o-Carboxyphenol; Acido O-idrossibenzoico (Italian);
Acido Salicilico (Italian); 2-hydroxy-Benzoic Acid;
o-Hydroxybenzoic Acid; 2-Hydroxybenzoic
Acid; Kyselina 2-hydroxybenzoova (Czech); Kyselina
Salicylova (Czech); Orthohydroxybenzoic Acid; |
| SMILES |
sodium salicylate
← sodium phenolate |
|
CLASSIFICATION
|
CARBOCYCLIC
CARBOXYLIC ACIDS
|
|
PHYSICAL
AND CHEMICAL PROPERTIES
|
| PHYSICAL
STATE |
white to off-white
crystalline powder |
| MELTING
POINT |
159
C |
| BOILING
POINT |
211
C |
| SPECIFIC
GRAVITY |
1.44 |
| SOLUBILITY
IN WATER |
Slight |
|
SOLVENT
SOLUBILITY
|
soluble in alcohol,
ether, boiling water, sparingly soluble in chloroform |
| AUTOIGNITION
|
540
C
|
| pH |
2.4
|
| VAPOR
DENSITY |
4.8 |
| NFPA
RATINGS |
Health: 0 Flammability: 1 Reactivity: 0 |
| REFRACTIVE
INDEX |
|
| FLASH
POINT |
|
| STABILITY |
Stable
under ordinary conditions. Light sensitive. |
|
GENERAL
DESCRIPTION & APPLICATIONS
|
Salicylic Acid is a white crystalline powder or needle-shaped crystals with
sweetish taste; soluble in acetone, ether, alcohol, boiling water, benzene and
turpentine, sparingly soluble in chloroformbenzene, slightly soluble in water;
melts at 158°C. The sodium salt form (sodium salicylate) is common commercially,
prepared from mainly sodium phenolate with carbon dioxide under heating and
pressure. It contains both a hydroxyl and a carboxyl group, which react with
either an acid or an alcohol. The carboxyl group forms esters with alcohols;
e.g. methyl salicylate is formed with methanol, which used in food flavorings
and preservatives; menthyl salicylate is formed with methanol, which is used in
suntan lotions. The hydroxyl group reacts with acetic acid to form
acetylsalicylic acid (called aspirin) which is the most widely common antiseptic
and antipyretic agent. Phenyl salicylate (called salol) is formed with phenol,
which is also used as an antiseptic and antipyretic agent. The sodium salt
(Sodium salicylate), a shiny white powder, is used for antiseptics preparations
and as a preservative. In addition to its analgesic and antipyretic properties,
salicylic acid possesses keratinolytic properties and fungicidal properties. It
ans its derivatives are used in the treatment of hyperkeratotic, dandruff,
ichthyosis and psoriasis as well as in the treatment of fungal skin infections
such as tinea. Para-Aminosalicylic acid (abbreviated PAS and PASA) is an
analogue of para-aminobenzoic acid (abbreviated PABA) that inhibits folic acid
synthesis in Mycobacterium tuberculosis and is bacteriostatic, inhibits growth
and multiplication of the tubercle bacillus. Para-Aminosalicylic acid and its
sodium salt (sodium p-Aminosalicylate) are bacteriostatic against mycobacteria
and used in the treatment of tuberculosis; administered orally. Brand names are
Tubasal, Nemasol Sodium and etc. Aminosalicylic acids are pharmaceutically
active ingredients including anti-infectives against colds, flu, or other virus
infections. Mesalamine (5-aminosalicylic acid, abbreviated 5-ASA) an active
metabolite of sulfasalazine, used to treat inflammation of the rectum and lower
colon, mild to moderate ulcerative colitis proctosigmoiditis, and proctitis. Para-Aminosalicylic acid
(4-hydroxybenzoic
acid) is used as an intermediate of bacteriostatic agent
specially for parabens (alkyl esters of
p-hydroxy benzoic acid) which used in food and personal care products as a preservative.
It is applied in the production of liquid crystal polymers.
It is also used as an intermediate of dyes, insecticides,
pharmaceutical, pesticides and
other chemical compounds.
Salicylic Acid and its derivatives are important for the preparation of other
pharmaceutical products, dyes, flavours, and preservatives. Topical keratolytic agents are beta hydroxy acids such as salicylic acid.
KERATOLYTIC
AGENTS
|
Keratolytic
|
CAS
RN
|
| Acitretin |
55079-83-9 |
| Alcloxa |
1317-25-5 |
| Aldioxa
|
5579-81-7 |
|
97-59-6 |
| Benzoyl peroxide |
94-36-0 |
| Dibenzothiophene |
132-65-0 |
| Etarotene |
87719-32-2 |
| Etretinate |
54350-48-0 |
| Isotretinoin |
4759-48-2 |
| Motretinide |
56281-36-8 |
| Nordihydroguaiaretic
acid |
500-38-9 |
| Podofilox |
518-28-5 |
| Podophyllum resin
|
9000-55-9 |
| Resorcinol
|
108-46-3 |
| Resorcinol monoacetate
|
102-29-4 |
| Salicylic acid |
69-72-7 |
| Sumarotene
|
84264-84-6 |
| Sumarotene |
105687-93-2 |
| Tazarotene |
118292-40-3 |
| Tetroquinone |
319-89-1 |
| Tretinoin |
302-79-4 |
|
| SALES
SPECIFICATION |
|
BP
GRADE
|
|
APPEARANCE
|
white to off-white
crystalline powder |
| ASSAY |
99.0%
min |
|
MELTING
POINT
|
157
min
|
|
HEAVY
METALS |
20ppm
max
|
|
WATER
|
0.5%
max
|
|
ASH
|
0.1%
max
|
|
LOSS
ON DRYING
|
0.5%
max
|
|
TECH
GRADE
|
|
APPEARANCE
|
white to off-white
crystalline powder |
|
ASSAY |
98.5%
min |
|
MELTING
POINT
|
155
C
|
|
WATER
|
0.5%
max
|
|
RESIDUE
ON IGNITION
|
0.5%
max
|
| TRANSPORTATION |
| PACKING |
25kgs
in bag |
| HAZARD
CLASS |
Not regulated |
| UN
NO. |
|
| OTHER
INFORMATION |
|
Hazard Symbols: XN, Risk Phrases: 24-41,
Safety Phrases: 26-39
|